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Molecular Templates has built a platform that allows for the rapid identification of therapeutic leads with a novel mechanism of cell kill specifically targeted to cell surface markers. The company has created a candidate library containing billions of ribosome-inhibiting proteins (RIPs) derived from bacterial toxins in which each variant possesses a distinct binding affinity.

This toxin variant library can be rapidly and efficiently screened against known cell-surface targets or in an etiology-specific manner where targets are not identified a priori. The screening criteria is the direct cell-kill ability of the variants. Because toxin scaffolds are used, the PK/PD of the leads in humans is predictable and validated.

©2009 Molecular Templates Inc.